Growth hormone and malignancy.

Papillary Carcinoma of Thyroid Gland in a Patient Treated with Recombinant Growth Hormone

The first successful treatment of growth hormone (GH) deficient children with GH extracted from human pituitary was introduced during late 1950's.  The subsequent availability and use of recombinant GH (rhGH) for different clinical conditions raised the question of whether this new therapeutic modality increases the risk of certain conditions such as leukemia or malignancy.  Herein, we report o...

Comparison of Growth Impairment in Pediatric Patients with ALL, NHL Treated with Chemotherapy alone and Chemoradiotherapy

Introduction: Acute Lymphoblastic Leukemia (ALL) and Non Hodgkin’s Lymphoma(NHL) are the most common cancers in childhood and  adolescence. Most children with ALL and NHL have long term survival (>80%). Endocrinopathy is a common complication in pediatric cancers following the treatment (20-50% prevalence), in addition, cytotoxic chemotherapy and radiotherapy can influence side effect on growt...

Comparison of Expression of Growth Hormone-Releasing Hormone and Its Receptor Splice Variant 1 in Different Stages of Endometriosis

The effects of short-term growth hormone (somatotropin) bath on some growth and immunity indices in the early stages of growth in rainbow trout (Oncorhynchus mykiss)

This study was conducted to determine the effect of growth hormone on some growth and immunity parameters at three stages of rainbow trout eyed egg, alvin and fry. The experiment was carried out in 4 treatments with concentrations of 0, 0.1, 0.5 and 1 mg/l of somatotropin hormone. For permeability, different experimental groups were treated with sodium hypochlorite (0.005 %) for 15 seconds befo...

The relationship between growth hormone polymorphism and growth hormone receptor genes with milk yield and reproductive performance in Holstein dairy cows

The aim of this study was to investigate the potential association between growth hormone GH/AluI and growth hormone receptor GHR/AluI polymorphisms with milk yield and reproductive performances in Holstein dairy cows in Iran. Blood samples of 150 Holstein cows were collected and their genomic DNA was extracted using Gene-Fanavaran DNA extracting kit. Fragments of the 428 bp of exon 5 growth ho...